AZT

AZT The AIDS virus is one of the most deadly and most wide spread diseases in themodern era. The disease was first found in 1981 as doctors around the United Statesbegan to report groups of young, homosexual men developing a rare pneumoniacaused by an organism called Penumocystis carini. These patients then went on todevelop many other new and rare complications that had previously been seen only inpatients with severely damaged immune systems. The Center for Disease Control inthe United States named this new epidemic the acquired immunodeficiency syndromeand defined it by a specific set of symptoms. In 1983, researchers finally identified thevirus that caused AIDS. They named the virus the human immunodeficiency virus, orHIV. AIDS causes the immune system of the infected patient to become much lessefficient until it stops working altogether.The first drug that was approved by the American Food and Drugadministration for use in treating the AIDS virus is called AZT, which stands forEngli sh: Synthesis of AZT from thymidyne Polski: S...azido-thymidine. AZT was released under the brand name of Retrovir and it's chemicalname is Zidovudine, or ZDV. The structural name of AZT is 3'-azido-3'-deoxythymidine. AZT works by inhibiting the process of copying DNA in cells. Morespecifically, AZT, inhibits the reverse transcriptase enzyme, which is involved in theDNA replication process. When DNA is replicating in a cell, there is a specific enzymethat works along one side of the original DNA strand as the DNA is split into twostrands, copying each individual nucleotide. This enzyme is only able to work in onedirection along the nucleotide string, therefore a different enzyme, or rather a series ofdifferent enzymes is required to work in the opposite direction. Reverse transcriptaseis one of the enzymes that is required to work...

CBA Leads Bank Share Price Correction

The article is entitled â€Å"CBA leads bank share price correction† is analysed in this report. The article primarily discuss how share price has plunged deeper in the major banks into correction territory following a weak trading update arising from Commonwealth Bank disclosing increasing costs, narrowing margin of profit and escalating loan losses. It indicates that CBA has agonized its sharpest day-to-day share price plunged ever since global financial crisis. CBA’s shared price plummeted 5.9% to 82.98 dollars culminating to a further worsened investor sentiments. This followed a third-quarter unchanged profit report by CBA remain constant at $2.2 billon. This plunged has adversely affected CBA’s competitors including Westpac, NAB, and ANZ Banking Group. The article concludes that the next immediate teething problem for the sector is profit result for NAB merged with 3 big 4 trading ex-dividend over the following week. The accounting theory used in this analysis is Efficient Market Hypothesis (EMH)-semi strong form (SSF). EMH describes an investment theory that posits it is not possible to ‘beat the market† due to stock market efficiency that makes available share prices to incorporate as well as reflect every relevant information. Stock trade always at their fair value on stock exchanges which make it an impossibility for investors to buy undervalued stocks and sell stocks for exaggerated prices (Chi, Tripe & Young, 2014). Hence, it remains an impossibility to outperform the entire market via expert stock selection and market timing. The investor can solely likely to acquire higher returns through the purchase of riskier investments. SSF implies every public information is computed into current share price of stock implying neither fundamental nor technical examinations can be utilized to accomplish superior returns. Hence, solely information hidden from the public is suggested to benefit the investors looking to earn abnormal ROI as every other information remains accounted. There is a direct relationship between the share price plunge and the information availed to the public by the Commonwealth Bank (CB) which is what SSF posited above. The plunge in shares in leading banks plunged deeper into correction territory only following a weak trading update given by the CB. This indicates that the public had the information that costs were rising, profit margins were narrowing and the loans losses were rising. According to SSF, every information available to the public is accounted for in the stock prices and no amount of technical or fundamental analysis gives superior returns. This describes why the investors used CB’s update to punish the shares in CBA thereby plunging 5.9%. Indeed, CLSA Brian Johnson confirmed this hypothesis by stating that investors had already seized on the bad news of CBA relating to margins, bad loans and costs. Moreover, the David Ellis confirmed the SSF hypothesis by stating that the investors used the information thereby flocking to banks to exploit their huge dividends as bank shares were being sold off due to increasing yields hence ‘yield trade’. It is also believed that investors could be starting to question whether the fundamentals could justify the hideously expensive valuation, anchored on measures like price-to-earnings as well as price-to-book ratios. This means that the investors are aware of the SSF hypothesis that takes into calculation all public information into present stock share price and hence fundamental analysis cannot be applied to achieve gains by banks (Leuthold & Hartmann, 2013). Due to EMH, the investors behaved in the manner above because they believed that the market remains ubiquitous and, therefore, no quantity of analysis could assist them achieve alpha returns (Groenewold, 2012). Thus, because market is a reflection of its participants, the market is, therefore, all knowing, and becomes unbeatable. It knows the right value to assign to a given stock as stated by EMH. This explains the above plunges in bank share prices (Aitken, Almeida & McInish, 2013).   Ã‚  Ã‚   From the above information, it has been demonstrated that the share prices have extremely plunged due to the update by the Commonwealth Bank. This supports the EMH-semi strong form which posit that all publicly available information is accounted for and hence no degree of technical or fundamental analysis can help investors acquire alpha returns (Schenone, 2014). Aitken, M., Almeida, N., & McInish, T. H. (2013). Financial analysts and price discovery. Accounting & Finance, 48(1), 1-24. Chi, J., Tripe, D. W., & Young, M. R. (2014). Do exchange rates affect the stock performance of Australian Banks?. Available at SSRN 965599. Groenewold, N. (2012). Share market efficiency: tests using daily data for Australia and New Zealand. Applied Financial Economics, 7(6), 645-657. Leuthold, R. M., & Hartmann, P. A. (2013). A semi-strong form evaluation of the efficiency of the hog futures market. American Journal of Agricultural Economics, 61(3), 482-489. Schenone, C. (2014). The effect of banking relationships on the firm's IPO underpricing. The Journal of Finance, 59(6), 2903-2958.

Obesity Health Advocay Campaign Research Paper Example | Topics and Well Written Essays - 750 words

Obesity Health Advocay Campaign - Research Paper Example Despite these concerns, the rate of social expenditure in alcoholic drugs and narcotics has subsequently increased and are regarded as the major factors contributing to obesity. Due to the poor health and dietary habits of most Americans, there have been campaigns developed to stop the effect of this disease. To be an effective advocate campaigner it is important first to have clear objectives on how you wish to attain your goals. For this reason it is important to get powerful individuals who have high score chances of standing against a large opponent. It is important also to understand working under the public eye involves constant scrutiny and criticism. Provision 8.1 of ANA code of ethics requires that the nursing profession be committed in promoting health and welfare and safety of all people. Our aim is to reduce the number of people suffering from obesity from current 35.7% to less than 5% in the next 10 years. This will be done through health programs aimed at promoting good diet for the community and the public in general. This will be conducted through advertisements and home visits in areas where the cases of obesity are highly prevalent. We target schools and other institutions as we aim at providing guidance on how to end up with a healthy life. We will also get the community support by making three lists of our allies, opponents and unsure people to help us identify our target audience. Before doing this it will be necessary to acquire an IRB approval since we shall be dealing with human subjects. This research will provide hotlines to all the subjects to freely report on incompetent, unethical, illegal, or impaired practice behaviors or situations. However, during this time ethical dilemmas usually arise. One can be in a dilemma on whether to launch attacks on those who are on the opponent side or not. We shall also constantly remind our nurses that each one of them is accountable for individual practice according to the

The report Essay Example | Topics and Well Written Essays - 2000 words

The report - Essay Example The company has grown extensively over the past few decades and opened thousands of stores across America, China, and other countries across the globe. The retail business in US has undergone rapid transformation since the emergence and growth of Wal-Mart culture. The Wal-Mart business model is being widely adapted and implemented by most competitive agencies owing to its successful operations and increasing revenues. The Wal-Mart has emerged as a popular brand name among the consumers looking for competitive rates and a comfortable shopping experience. The success of the business model adopted by Sam Walton is attributed to a deeper understanding of consumer behaviour and consumer psychology that plays actively while making a purchase decision. â€Å"The secret of successful retailing is to give your customers what they want. And really if you think about it from your point of view as a customer, you want everything: a wide assortment of good quality merchandise; the lowest possible prices; guaranteed satisfaction with what you buy; friendly, knowledgeable service; convenient hours; free parking; a pleasant shopping experience† (Walton, 1992). Wal-Mart procures goods from suppliers at low cost that translates to low pricing offered to the consumers. The incredibly low prices offered by the stores attract increased number of consumers to Wal-Mart and this is a major factor behind the success of Wal-Mart. The customers at Wal-Mart are offered with a wide variety of products at comparatively low rates that accounts for a conve nient shopping experience under a single roof. Technology has equipped the workforce with speed and accuracy that has enhanced overall productivity and efficiency within any organization. Innovation is the key to success in most business enterprises and it is evident in the way Wal-Mart has leveraged the use of innovative technology to gain cost advantage in their retail operations. The use of bar code technology has helped the

Palestine And Isreal Conflict Essay -- essays research papers

Territorial disputes over which religion should have control over the holy lands have been ongoing for about two thousand years with little to no resolution in sight. Everyday, on the news, there is a story about how there was retaliation over the killing of a Palestinian or Israeli. As a result of these more are killed leading to the cyclical pattern of retribution. This conflict has diminutive weight in the eyes of the people of the world since it has been carried on for so long. The argument for both groups is a claim that Jerusalem is the rightful possession of their religion and the key to the survival of their cultures. Promises for peace are frequent but never upheld by either side. As the everyday struggle for peace continues little is accomplished to up hold that pledge for peace to end the violence and hate. The shouting voices of the Palestinian People in the streets cry out in anger, †Down the olive branch, long live the gun.† There is more to the never endin g holy war than that of which the media allows us to see, the fear and loathing for that of a better life. The trifling stories of the individual are frequently untold even though they are a transgression committed against personal liberties.   Ã‚  Ã‚  Ã‚  Ã‚  When the rest of the world gets involved it becomes a much more complicated affair than if people were to leave it alone for the two countries to work it out between themselves. The Palestinians and the Israelis could view intervention as siding with one side or the other leading to defensiveness and therefor slowing down or sometimes halting any progress that may have been made. Since the late 1940’s the Untied Nations has become increasingly more involved in order to put and end to the human suffering of the people in that region. By having the two groups send representatives to the Netherlands, which is seen as a non-partisan territory that would be less intrusive in negotiations. The United Nations and the Palestinian Liberation Organization have assembled and come to resolutions that were thought to be in the best interest of each of the countries in order to instill peace and bring order to the region. By this process there has been much animosity bui lding within the population with civilians killing soldiers and vice versa as seen on the news reports.   Ã‚  Ã‚  Ã‚  Ã‚  In around the year 750 A.C.E the A... ...and being helpful and non-intrusive in the peace making process. Since the UN General Assembly met in 1947 and recommended that the land be partitioned among the two groups. In this the Jewish people took less land than they originally had previously wished to control. The PLO was formed of the different Arab groups that wanted to control the Israeli occupied territory. This is an example of how intervention from groups could be used to further their cause. In 1974 the UN recognizes the PLO as a legitimate representative body of the Palestinian people and therefore fueling the nationalism within the hearts of its people which is good for their cause. After the Israelis had defeated the Arabic aggressors they then were forced by the UN to return the settlements taken in the war. This action would not have been taken if the Arabs were to win. The PLO would have let them keep the lands since their primary goal was to destroy Israeli. Because of these efforts to maintain peace it is a better premise than if it were to be left up to the factions to settle disputes for themselves. The UN has used their influence to pursue a more peaceful resolution and to save the lives of the citizens.

Michelangelo showing his religion Essay

Michelangelo painted frescoes on the ceiling of the Sistine Chapel, and made a sculptor of David. Both the painting and the sculptor point to the great deal knowledge Michelangelo has of the Bible. On the Sistine Chapel’s ceiling he painted scenes from the book of Genesis, and David the person comes from the first Book of Samuel. Michelangelo has background with the Christian Church and did many sculptures and painting for the church. The religious influence of the church could not be avoid by Michelangelo. He had been introduced to it very early in his life. Sistine Chapel’s ceiling was a very religious painting job done by Michelangelo. The Sistine’s ceiling shows Michelangelo’s knowledge of Bible events. It has Prophets and Sibyls painted on it, which are very religious figures. It shows the beginning of time to the Flood with Noah’s Great Ark. The sculpture of David was done for Saint Peters Cathedral. It gave new meaning to life for the people of Florence. David was not only thought of as a Messiah by the Old Testament Prophets, but also by the people of Florence. He brought hope as a person and a statue. Michelangelo not only showed that religion was important to him through his works, but also immortalized part of the Bible. Michelangelo showing his religion The Sistine Chapel is one of the most visited places in the world, and the Colossal David is one of the most well-known sculptors in the world. These two great works of art affect whatever people look at them. Without knowing it people get a brush of religion. Michelangelo shows his view of religion to people even after he has died. Michelangelo lived a life of art. From the day he was born to the day he died he lived art. Michelangelo was one of, if not the best sculptor and painter ever to touch foot on this earth. He any painter made a â€Å"shining† in  religious art it was Michelangelo. The Sistine Chapel is located in the Vatican City. This is where Saint Peter’s Basilica was built. The Sistine Chapel was a private room for the Pope. Pope Julius II asked Michelangelo to paint on the ceiling. He almost turned it down because he thought of himself as a sculptor not a painter. He took the painting job on to prove to people that he could paint even though he did not like to do it. Through the works of the Sistine Chapel’s ceiling and the statue David, Michelangelo immortalized his Christian religion. Background: Michelangelo Michelangelo (Figure 1) was born on March 6, 1475 in a town called Caprese, a region of Tuscany, near Florence. Michelangelo’s father was Lodovico Buonarroti Simon, and his mother Francesca Miniato del Sera. Michelangelo’s mother decided to send the baby Michelangelo away to be looked after for a while by a stonecutters wife, because his dad didn’t have a job and his family life was difficult. â€Å"Michelangelo said his love for stone came from the milk of stonecutters wife who nursed him as a baby†(Richmond pg. 24). Michelangelo wanted to be an artist but his father did not agree. When Michelangelo was seven he was sent to a basic school, he was always sneaking off and drawing something. After many long arguments with his father, Michelangelo finally convinced him that sculpturing and block carving are different. Michelangelo was then allowed to study the arts. Michelangelo’s father put him in the workshop of the painter Domenico Girlandaio. After two years Michelangelo studied at a sculpture school in the Medici gardens. He wanted to join a bottega, which is a workshop where young men could learn art with masters. At age 13 he was allowed to join, and shortly thereafter was invited into the household of Loreczo de’ Medici, the Magnificent. Because Michelangelo was so good at sculpting, a fellow student, Pietro Torrigiano, got jealous and punched Michelangelo in the nose , giving him a prize fighters nose that makes him so recognizable in his portraits. When Michelangelo’s talent became known, he no longer paid for the lessons, instead he was paid. â€Å"Michelangelo produced at least two relief sculptures by the time he was sixteen years old, the battle of the features and the Madonna of the stairs†(Gilbert pg.68). This showed that Michelangelo had achieved a personal style at a very early age. Most sculptors have not finished learning about style, let alone have their own style by the age of sixteen. Michelangelo died on February 18, 1564 at almost 90 years old, he was hard at work on a statue. Background: Sistine Chapel Ceiling In 1508 Michelangelo took on the ceiling of the Sistine Chapel (Figure 2) after Julius offered it to him. Michelangelo was annoyed, since he was a sculptor primarily. One reason it was annoying was â€Å"†¦ ceilings in churches and chapels are minor compared to the walls, which in this instance had been frescoed thirty years before by Botticelli, Ghirlandaio, and other distinguished painters†(Gilbert) Ceiling normally did not show scenes, but only a single feature or ornament. To make his work more eloquent Michelangelo got permission to paint scenes on the ceiling as well as single figures. Of course they are awkward to see, but the power and success of the work was so great that for centuries this unreasonable scheme of painting scenes on the ceiling was followed in other buildings without special thought. He had to unmanageably stand on the scaffolding with his head thrown back on his shoulders. â€Å"Michelangelo divided up the area with a very original framing system in order to organize the large scenes, the large single figures retained from the first proposals, and a host of smaller representations.†(Gilbert pg. 90) He choose nine scenes from the Book of Genesis- three of the creation of the world, three of Adam and Eve, and three of Noah-â€Å"†¦ they were inevitable choices, because scenes of Moses had been painted on the walls, and the natural narrative sequence is downward.† The twelve large figures are prophets and sibyls- sibyls being women appearing in various pagan mythologies, such as the Delphis Oracle. Michelangelo started painting at the end of his narrative, with the Noah stories, and the adjacent prophets  and sibyls, then moving with both scenes and figures toward the other end. It is surprisingly little noticed that the first seven prophets and sibyls were painted in one size and the last five in a larger size. All fit nicely into their painted frames, and the inconspicuousness of the change in size is a token of the subtlety of the frames. The change itself has a good artistic reason, which is that the scenes first painted, of Noah and Eve, contain quite a few figures, while those painted later, of god creating the world and man, contain only one or two, they needed to be larger in order to fill the space which was given to him from the framing system. â€Å"The point where the scale of the figures changes is also a point where, it seems, he took a rest for several months†(Levy pg.74). The break did not affect the splendid painting on the ceiling. Religion on the Sistine Chapel Ceiling The religion aspect of the Sistine chapel is overwhelming. It pours out of every crack, from painted over frescoes to sculptures. On the ceiling ,as mentioned above, is painted three scenes of the creation of the world, three scenes of Adam and Eve, and three scenes of Noah and the Flood, along with scared sibyls and prophets. The sibyls and prophets come from the pagan religion which Michelangelo was introduced to by one of his early teachers. The sibyls were interpreted as having made prophesies similar to those of the Old Testament prophets. The scenes on the ceiling come from the book of Genesis, which comes from the Bible. Michelangelo was chosen to paint the Sistine Chapel’s ceiling but he got to pick what he painted, with the approval of the Pope of course. He chose scenes from both the Pagan religion and the Bible, which makes a religious influence evident. Michelangelo was knowlegdable of the Bible, without having knowledge of the bible how could he have known about the specific happenings. Background: David David (Figure 3) was born in 1040 B.C. and became King of Israel. He first  distinguished himself by slaying Goliath. Goliath was a giant born in Gath who Challenged the army of Israel. He was Six cobils and a span tall, which is about 11 feet. David was taken into Saul’s household, the king of Israel. There he became too popular for his own good and had to flee from Saul’s jealously. After the death of Saul’s he was elected king of Judah and reigned for seven and one half years in Hebien. When Ishbosheth, the king after Saul, died, David was chosen by all Israel as king. He conquered Jerusalem and made it the political and religious center of his kingdom. To the Old Testament prophets David became a type of Messiah. The story of David and Goliath comes from the Bible from Book one of Samuel Chapter 17. In verse 46 of that Book David said to Goliath: This day will the Lord deliver thee into mine land; and I will smite thee, and take thine head from thee; and I will give the carcasses of the host of the Philistines this day unto the fouls of the air, and to the wild beasts of the earth; that all the earth may know that their is a God in Israel. The Cathedral asked Michelangelo to sculpted a Colossal David . Michelangelo accepted the offer and guaranteed to complete a Colossal David for the Cathedral in 2 years. Around the chunk of marble he obtained for this feat he built a shed, which was locked at all times. â€Å"He did not launch immediately into the stone as legend had it, making chips fly off violently as he struggled to set free the image he saw within†(Tolnay pg. 41). For many weeks he examined and measured his material to see what pose it could accommodate. He made sketches of possible positions, and carefully detailed drawings from models for the parts of the figure. He tested out his image in wax on a small scale. â€Å"Then, and only then did he pick up a point and a mallet to make the first rough spilters fly clattering to the floor†(Tolnay pg. 42). Although it occupied him nearly three years to complete, it was worth the wait for the people living in Florence. â€Å"Michelangelo phrased his first titan in terms of a civic guardian, symbol of righteousness. None of his later masterpieces so profoundly affected his fellow citizens†(Gilbert pg.82). The author Gilbert writes: In the precision of its anatomy one can recognize the scientific spirit of investigation of the Florentines; in the forms, which are full of strength, and in the noble, proud face, one finds the heroic concept of man as a creature who is free and master of his own destiny(page 85). Technically this statue marked a change in Michelangelo’s development. In a single work he achieved the difficult transition from normal scale to the colossal without a flaw, setting back the chin slightly so that it would not cut off too much of the other features from the spectator’s view, building out the nose and forehead. Religion in David David comes straight from the Bible. In the following lines, from Book one of Samuel, Chapter 17, verses 49 through 51, it tells how David came to slay the giant Goliath: 49 And David put his hand in his bag, and took thence a stone and slang it, and smote the Philistine in his forehead, that the stone sunk into his forehead; and he fell upon his face to the earth 50 So David prevailed over the Philistine with a sling and with a stone, and smote the philistine, and slew him; but there was no sword in the hand of David. 51 Therefore David ran, and stood upon the Philistine, and took his sword, and drew it out of the sheath therefor, and slew him, and out off his head therewith . And when the Philistines saw their champion was dead, they fled. Religion in David is undeniable. He is a part of the Bible therefore a part of religion. A religion which Michelangelo learned about since he was an infant with the stonecutter’s family. David was sculpted having the look of fear, as if the sculptor knew what David was going through at that exact point in the battle with Goliath. The religion Michelangelo shows through David is immense. Conclusion Both the painting of the Sistine Chapel Ceiling and the sculptor of David reflect the knowledge that Michelangelo has of Pagan religion, but mostly of the Bible. Clifton Harby Levy writes: Religion was the supreme interest of the leaders in human thought during this century, when the Church played so large a part in the destiny of nations, and very naturally any and every artist who felt the pulse of his time was impelled to prove his power by the skill with which he presented sacred subjects. Art was religious because the people were religious†¦(page xi). In other words, art could make or break a nation. Michelangelo was trying to make Italy, by giving them the best religious art you could find. In a way the art helped the people survive, fight, and showed them what they could believe in to get away from the agony of living a life of torment. These works illustrated points from the Bible in such a magnificent manner, that they have changed life from the day they were put on display to the present. Religion was, is, and always will be a powerful thing. Works Cited Gilbert, Creighton. Michelangelo On and Off the Sistine Ceiling. New York: George Braziller, 1994. Levy, Clifton Harby. The Bible in Art. New York: Covici Friede, 1936. Richmond, Robin. Introducing Michelangelo. New York: Walker, 1984. Salvini, Roberto. Michelangelo. Connecticut: Masterworks Press, 1976. Tolnay, Charles de. Michelangelo Sculptor-Painter-Architect. London: Princeton University Press, 1975. Works Consulted Bellosi, Luciano. Michelangelo: Painting. New York: Bellview, 1946. Buonarroti, Michelangelo. Michelangelo, the painter. Italy: Harry N. Abrams, Inc., 1964 Chase, Alice Elizabeth. Famous artists of the past. New York : Platt & Munk, 1964. Coughlan, Robert. The world of Michelangelo, 1475-1564. Italy: Time, inc., 1966 Day, Thomas. Where have you gone, Michelangelo? : the loss of soul in Catholic culture. New York : Crossroad, 1993. De Vecchi, Pierluigi. Michelangelo. New York : H. Holt, 1992. Rasponi, Simonetta. Michelangelo. Italy: Avenel Books, 1978. Ripley, Elizabeth Blake. Michelangelo : a biography. New York, Oxford University Press, 1953.

The Quality Of Self Reliance - 953 Words

As back in the Greek time, it is stereotypically believed in people that they were created by the Gods and everything happened or would happen in their life is also pre-set by the Gods. Plebeian were often restrained by such a typical perception, therefore they insisted that life was controlled by their own destiny, which was unable to deny. Though Oedipus and Socrates demonstrated their wisdom that was superior than the Plebeians when facing puzzles, the types of wisdom they possessed were different to some extent, and this is the main factor that caused different experience in their later life. The quality of self-reliance is a representation to imply on the traditional belief, which is that a hero-type would be willing to fight against own destiny, though the consequence would mostly be tragic. Such inspiring quality was spread for generations as a symbol of the Greek. Self-reliance symbolises the common understanding that both Oedipus and Socrates possessed when facing puzzles. Oedipus applied his wisdom when facing the Sphinx alone and resolved the puzzles without any help â€Å"from the birds†. The answer of the puzzle, which is human, reflected on the real puzzle at that time, which is that human is the biggest puzzle among the world. Plebeians were somehow afraid of the Gods because they didn’t know much about human as themselves. The wisdom Oedipus was beyond others and also beyond the time, so that human started to know about themselves, thus overcome the fear ofShow MoreRelatedTranscendentalism : Ralph Waldo Emerson And Henry David Thoreau967 Words   |  4 Pages This is a perfect explanation for what a transcendentalist is and what makes them so special. There are several important transcendentalist ideas that were expressed by Emerson and Thoreau, but few are as necessary as these; nature, self-reliance, and life quality. Nature is one of the most essential transcendentalist ideas that Emerson and Thoreau explained. 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